Evidence mapPaperPMID 40649960Full record

ReviewInternational journal of molecular sciences2025

Phage-Microbiota Crosstalk: Implications for Central Nervous System Disorders.

Valentina Salari, Edoardo Parrella, Francesca Mengoni, Laís Cintra, Giuseppe Bertini, Paolo Francesco Fabene

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valentina SalariSection of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy.
Edoardo ParrellaSection of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-0365-5144
Francesca MengoniSection of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy.
Laís CintraSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, Faculty of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-2147-2010
Giuseppe BertiniSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, Faculty of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-6031-5130
Paolo Francesco FabeneSection of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-9644-4399

Funding

Excellence Project 2023-2027 of the Department of Neuroscience, Biomedicine and Movement Sciences of the University of Verona, funded by the Italian Ministry of University and Research Excellence Project 2023-2027Fondazione Cariverona 2022-ID52251-2022.008
6 · The paper itself

Abstract

The gut microbiota constitutes a complex community of microorganisms (including bacteria, viruses, fungi, and protozoa) within the intestinal tract. Over the years, an increasing number of studies have highlighted the bidirectional communication between the gut microbiota and the central nervous system (CNS), a relationship commonly referred to as the "microbiota-gut-brain axis". In particular, the crosstalk between the gut microbiota and the brain has been associated with the pathogenesis and progression of various CNS disorders. Phages, or bacteriophages, viruses that specifically infect bacteria, constitute the most abundant viral component within the gut microbiota. However, despite their abundance and significance in the gut microbial community, studies exploring the relationship between phages and the CNS remain surprisingly limited. This review examines the biological interplay between gut-resident phages and the CNS. Furthermore, we discuss the current literature linking phages to CNS-related pathologies.

Indexed as

BacteriophagesCentral Nervous System DiseasesGastrointestinal MicrobiomeAnimalsBacteriaCentral Nervous SystemHumansbacteriabacteriophagesbraincentral nervous system (CNS)gutmicrobiotaphages

Identifiers

PMID40649960
PMCPMC12249656

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.