Evidence map›Paper›PMID 40649961›Full record

ArticleInternational journal of molecular sciences2025

Role of Serotonin, Membrane Transporter, and 5-HT2 Receptors in Pathogenesis of Atherosclerotic Plaque Formation in Immature Heterozygous Low-Density Lipoprotein-Receptor-Deficient Mice.

Dinara Sadykova, Razina Nigmatullina, Karina Salakhova, Evgeniia Slastnikova, Liliya Galimova, Chulpan Khaliullina, Elena Gafurova, Dmitry Tsyplakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dinara SadykovaDepartment of Hospital Pediatrics, Kazan State Medical University, 420012 Kazan, Russia.
Razina NigmatullinaDepartment of Normal Physiology, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0002-4686-1231
Karina SalakhovaDepartment of Hospital Pediatrics, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0001-7327-7025
Evgeniia SlastnikovaDepartment of Hospital Pediatrics, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0002-1732-7443
Liliya GalimovaDepartment of Hospital Pediatrics, Kazan State Medical University, 420012 Kazan, Russia.
Chulpan KhaliullinaDepartment of Hospital Pediatrics, Kazan State Medical University, 420012 Kazan, Russia.
Elena GafurovaForensic Histology Department, Republican Bureau of Forensic Medical Examination, 420029 Kazan, Russia.
Dmitry TsyplakovDepartment of General Pathology, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0003-2593-4478

Funding

Russian Science Foundation 23-15-00417
6 · The paper itself

Abstract

Familial hypercholesterolemia leads to the early development of cardiovascular diseases at a young age due to the prolonged exposure of the arterial vessel wall to high concentrations of atherogenic lipids. Serotonin plays a significant role in the development and progression of atherosclerotic processes. Monoamine has a damaging effect on the vascular wall, stimulates the proliferation of vascular smooth muscle cells and fibroblasts, and participates in platelet activation and aggregation. The aim of the work was the demonstration of the importance of serotonin, transporters, and receptors in the pathogenesis of atherosclerotic plaque formation. The study was performed on immature mice of the C57BL/6JGpt-Ldlr

Indexed as

AtherosclerosisPlaque, AtheroscleroticReceptors, LDLReceptors, Serotonin, 5-HT2SerotoninSerotonin Plasma Membrane Transport ProteinsAnimalsAortaFemaleHeterozygoteMaleMiceMice, Inbred C57BLReceptors, LDLReceptors, Serotonin, 5-HT2SerotoninSerotonin Plasma Membrane Transport Proteinscardiovascular diseasefamilial hypercholesterolemiamembrane serotonin transportermiceserotoninserotonin receptorsvascular smooth muscle cells

Identifiers

PMID40649961
PMCPMC12250590

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.