Evidence map›Paper›PMID 40649976›Full record

SynthesisInternational journal of molecular sciences2025

The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis.

Ana Maria Jiménez-García, Maria Eduarda Tortorella, Agnes Lumi Nishimura, Natalia Arias

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ana Maria Jiménez-GarcíaBRABE Group, Department of Medicine and Health Sciences, Faculty of Life and Natural Sciences, University of Nebrija, C/del Hostal, 28248 Madrid, Spain.ORCID 0000-0001-6400-3436
Maria Eduarda TortorellaInstitute Paulo Gontijo, R. Maj. Prado, 42-Indianópolis, São Paulo 04517-020, SP, Brazil.
Agnes Lumi NishimuraInstitute Paulo Gontijo, R. Maj. Prado, 42-Indianópolis, São Paulo 04517-020, SP, Brazil.ORCID 0000-0001-5295-797X
Natalia AriasBRABE Group, Department of Medicine and Health Sciences, Faculty of Life and Natural Sciences, University of Nebrija, C/del Hostal, 28248 Madrid, Spain.ORCID 0000-0001-5602-5854

Funding

European Union NextGeneration EU/PRTR CPP2022-009646European Union NextGeneration EU/PRTR PLEC2022-009464Ministry of Science and Innovation PID2023-151715OB-IOO
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are linked by shared genetic mutations and overlapping clinical features, forming a clinical spectrum. This systematic review and meta-analysis analysed 97 studies, including 3212 patients with key ALS/FTD gene mutations, to identify gene-specific behavioural profiles.

Indexed as

Amyotrophic Lateral SclerosisCognitionFrontotemporal DementiaMutationC9orf72 ProteinEndosomal Sorting Complexes Required for TransportHumansProgranulinsRNA-Binding Protein FUSSuperoxide Dismutase-1tau ProteinsC9orf72 ProteinC9orf72 protein, humanCHMP2B protein, humanEndosomal Sorting Complexes Required for TransportMAPT protein, humanProgranulinsRNA-Binding Protein FUSSOD1 protein, humanSuperoxide Dismutase-1tau Proteinsamyotrophic lateral sclerosis (ALS)behavioural symptomsC9orf72seqcognitive impairmentfrontotemporal dementia (FTD)genetic mutationsMAPTPGRN

Identifiers

PMID40649976
PMCPMC12250155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.