Evidence map›Paper›PMID 40650065›Full record

ArticleInternational journal of molecular sciences2025

The Neuroprotective Potential of Seed Extract from the Indian Trumpet Tree Against Amyloid Beta-Induced Toxicity in SH-SY5Y Cells.

Nut Palachai, Benjaporn Buranrat, Parinya Noisa, Nootchanat Mairuae

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nut PalachaiBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, MahaSarakham 44000, Thailand.ORCID 0000-0002-9672-9941
Benjaporn BuranratBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, MahaSarakham 44000, Thailand.
Parinya NoisaSchool of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.ORCID 0000-0002-1474-7792
Nootchanat MairuaeBiomedical Research Unit, Faculty of Medicine, Mahasarakham University, MahaSarakham 44000, Thailand.ORCID 0000-0002-6407-2463

Funding

Thailand Science Research and Innovation
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an unclear etiology. Multiple factors, including oxidative stress and the accumulation of amyloid beta (Aβ) protein in the brain, contribute to neuronal damage. This study investigated Aβ-induced oxidative stress and cellular damage in SH-SY5Y cells, as well as the neuroprotective potential of Indian trumpet tree seed extract (ITS). SH-SY5Y cells were co-treated with Aβ

Indexed as

Amyloid beta-PeptidesNeuroprotective AgentsPlant ExtractsSeedsTerminaliaAntioxidantsApoptosisCell Line, TumorCell SurvivalHumansMalondialdehydeOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseAmyloid beta-PeptidesAntioxidantsMalondialdehydeNeuroprotective AgentsPlant ExtractsReactive Oxygen SpeciesSuperoxide DismutaseAlzheimer’s diseasecAMP response element-binding proteinIndian trumpet treemitogen-activated protein kinasesneuroprotectionOroxylum indicum (L.) seedoxidative stressplant extractionprotein kinase B

Identifiers

PMID40650065
PMCPMC12250397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.