Evidence map›Paper›PMID 40650067›Full record

ArticleInternational journal of molecular sciences2025

GPX1 and RCN1 as New Endoplasmic Reticulum Stress-Related Biomarkers in Multiple Sclerosis Brain Tissue and Their Involvement in the APP-CD74 Pathway: An Integrated Study Combining Machine Learning and Multi-Omics.

Zhixin Qiao, Yanping Wang, Xiaoru Ma, Xiyu Zhang, Junfeng Wu, Anqi Li, Chao Wang, Xin Xiu, Sifan Zhang, Xiujuan Lang and 4 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhixin QiaoDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Yanping WangDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Xiaoru MaDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Xiyu ZhangDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Junfeng WuDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Anqi LiDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Chao WangDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Xin XiuDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Sifan ZhangDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Xiujuan LangDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Xijun LiuDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Bo SunDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Hulun LiDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.
Yumei LiuDepartment of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.

Funding

This study was supported by grants from the Special Project of Traditional Chinese Medicine in Heilongjiang Province of China ZYW2023-132
6 · The paper itself

Abstract

This study identified 13 endoplasmic reticulum stress (ERS)-related biomarkers associated with multiple sclerosis (MS) through integrated bioinformatics analysis (including weighted gene co-expression network analysis and machine learning algorithms) and single-cell sequencing, combined with validation in an experimental autoimmune encephalomyelitis (EAE) mouse model. Among them,

Indexed as

BrainCalcium-Binding ProteinsEndoplasmic Reticulum StressGlutathione Peroxidase GPX1Machine LearningMultiple SclerosisAmyloid beta-Protein PrecursorAnimalsAntigens, Differentiation, B-LymphocyteBiomarkersB-LymphocytesCell CommunicationGene Expression RegulationHistocompatibility Antigens Class IIHumansMendelian Randomization AnalysisAmyloid beta-Protein PrecursorAntigens, Differentiation, B-LymphocyteBiomarkersCalcium-Binding ProteinsGlutathione Peroxidase GPX1Histocompatibility Antigens Class IIinvariant chainbiomarkersendoplasmic reticulum stressimmune infiltrationmultiple sclerosisneuroinflammationscRNA-seqsnRNA-seq

Identifiers

PMID40650067
PMCPMC12249644

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.