A Mathematical Model of Metformin Action on COVID-19 Risk Infection in Cardiovascular Diabetic Patients Studied by FTIR Spectroscopy.

Evangelos Mylonas, Christina Mamareli, Michael Filippakis, Ioannis Mamarelis, Jane Anastassopoulou, Theophile Theophanides

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Evangelos MylonasDepartment of Digital Systems, University of Piraeus, 80 M. Karaoli & A. Dimitriou, 18534 Piraeus, Greece.

Christina MamareliAthens Institute for Education and Research, 9 Chalckokondili Str., 10677 Athens, Greece.

Michael FilippakisDepartment of Digital Systems, University of Piraeus, 80 M. Karaoli & A. Dimitriou, 18534 Piraeus, Greece.

Ioannis MamarelisCardiology Department, 401 Military General Hospital, Mesogeion Av. 138 & Katechaki Georgiou Str., 11527 Athens, Greece.

Jane AnastassopoulouAthens Institute for Education and Research, 9 Chalckokondili Str., 10677 Athens, Greece.

Theophile TheophanidesAthens Institute for Education and Research, 9 Chalckokondili Str., 10677 Athens, Greece.

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6 · The paper itself

Abstract

Several studies have revealed that patients with type 2 diabetes (T2D) infected with COVID-19 who were medicated with metformin showed higher recovery rates than those administered other antidiabetic drugs. To determine the mechanism of action of antidiabetic drugs against COVID-19, we developed a mathematical model that was based on the number of infected and recovered T2D patients. Moreover, the "diagnostic frequencies" of the infected T2D patients, determined using Fourier-Transform Infrared (FTIR) spectroscopy, were very helpful. In particular, the band at 1775 cm

Indexed as

Cardiovascular DiseasesCOVID-19COVID-19 Drug TreatmentDiabetes Mellitus, Type 2Hypoglycemic AgentsMetforminHumansMaleMiddle AgedModels, TheoreticalSARS-CoV-2Spectroscopy, Fourier Transform InfraredSpike Glycoprotein, CoronavirusThiazolidinedionesHypoglycemic AgentsMetforminSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ThiazolidinedionesCOVID-19diabetesFTIR spectroscopyinfected and recoveredinsulinmathematical modelmetforminthiazolidinediones

Identifiers

PMID40650107

DOI10.3390/ijms26136332

PMCPMC12249686

What Socratic holds

Texttitle and abstract

LicenceCC BY

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