Evidence map›Paper›PMID 40650109›Full record

ArticleInternational journal of molecular sciences2025

Inhibition of (p)ppGpp Synthesis and Membrane Fluidity Modulation by Diosgenin: A Strategy to Suppress

Yena Seo, Minjun Kim, Tae-Jong Kim

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Monocaprin, Monolaurin, and Monomyristin EradicatePharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yena SeoDepartment of Forest Products and Biotechnology, Kookmin University, 77 Jeongneungro, Seongbukgu, Seoul 02707, Republic of Korea.ORCID 0000-0001-6240-7445
Minjun KimDepartment of Forest Products and Biotechnology, Kookmin University, 77 Jeongneungro, Seongbukgu, Seoul 02707, Republic of Korea.
Tae-Jong KimDepartment of Forest Products and Biotechnology, Kookmin University, 77 Jeongneungro, Seongbukgu, Seoul 02707, Republic of Korea.ORCID 0000-0002-7483-0432

Funding

Korea Forest Service Government A2025-0012
6 · The paper itself

Abstract

Persister cells are a subset of bacterial cells that exhibit transient antibiotic tolerance without genetic resistance, contributing to the persistence of chronic infections. This study investigates the ability of diosgenin, a naturally occurring steroidal saponin, to inhibit persister cell formation in

Indexed as

Anti-Bacterial AgentsDiosgeninGuanosine PentaphosphateMembrane FluidityStaphylococcus aureusBacterial ProteinsGene Expression Regulation, BacterialMicrobial Sensitivity TestsStaphylococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsDiosgeninGuanosine Pentaphosphateantibiotic tolerancediosgeninmembrane potential modulationpersister cell(p)ppGpp synthesis inhibitionStaphylococcus aureus

Identifiers

PMID40650109
PMCPMC12249486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.