Evidence map›Paper›PMID 40650190›Full record

ArticleInternational journal of molecular sciences2025

The Role of Chemokines and Small Leucine-Rich Proteoglycans in Cardiac Remodeling in Immunosuppressant-Treated Male Rats.

Anna Surówka, Michał Żołnierczuk, Piotr Prowans, Marta Grabowska, Patrycja Kupnicka, Marta Markowska, Zbigniew Szlosser, Edyta Zagrodnik, Karolina Kędzierska-Kapuza

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna SurówkaDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, Poland.ORCID 0000-0002-8693-9259
Michał ŻołnierczukDepartment of Vascular Surgery, General Surgery and Angiology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-4539-7342
Piotr ProwansDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, Poland.
Marta GrabowskaDepartment of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, 71-210 Szczecin, Poland.ORCID 0000-0003-0861-0738
Patrycja KupnickaDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.ORCID 0000-0002-0756-6483
Marta MarkowskaDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, Poland.
Zbigniew SzlosserDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, Poland.
Edyta ZagrodnikClinical Department of Anesthesiology and Intensive Care of Adults and Children, Pomeranian Medical University, 72-010 Police, Poland.
Karolina Kędzierska-KapuzaDepartment of Gastroenterological Surgery and Transplantology, Centre of Postgraduate Medical Education in Warsaw, 137 Woloska St., 02-507 Warsaw, Poland.ORCID 0000-0001-5853-2147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines are low-molecular-weight peptides classified as cytokines with chemotactic properties. The chemokine CXCL13 and its receptor CXCR5 play a significant role in cardiac remodeling, and their expression is markedly increased in experimental models of heart failure. Increased CXCL13 activity is associated with the expression of fibromodulin, a proteoglycan that binds and cross-links collagen fibers. The stressed heart undergoes intensive remodeling, including fibrosis. In our experiment, we investigated the effect of the most commonly used triple immunosuppressive regimens on the expression of the CXCR5 receptor, the chemokine CXCL13, and fibromodulin in rat heart tissue. For this purpose, we used Western blot analysis and ELISA. The study was started on 36 rats divided into 6 groups, which received drugs for a period of 6 months. Our results suggest that the chronic use of calcineurin inhibitors in combination with mycophenolate mofetil is a significant stress factor for the heart, leading to abnormal remodeling of the extracellular matrix. The use of rapamycin may alleviate the negative effects of immunosuppressive therapy on the heart. Our results are consistent with the results of our previous studies and provide a basis for further work aimed at understanding the pathophysiology of the development of changes in the heart with individual immunosuppressive regimens.

Indexed as

ChemokinesImmunosuppressive AgentsProteoglycansVentricular RemodelingAnimalsMaleMycophenolic AcidMyocardiumRatsChemokinesImmunosuppressive AgentsMycophenolic AcidProteoglycanscardiovascular diseaseschemokinesCXCL13CXCR5fibromodulinheart failureimmunosuppressive treatment

Identifiers

PMID40650190
PMCPMC12249708

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.