Evidence map›Paper›PMID 40650274›Full record

ArticleInternational journal of molecular sciences2025

Tandem Mass Tags Quantitative Proteomics Reveal the Mechanism by Which Paeoniflorin Regulates the PI3K/AKT and BDNF/CREB Signaling Pathways to Inhibit Parkinson's Disease.

Zhen Feng, Chang Jin, Yue Zhang, Huiming Xue, Yongxing Ai, Jing Wang, Meizhu Zheng, Dongfang Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen FengCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.ORCID 0009-0009-1445-0591
Chang JinCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.
Yue ZhangCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.
Huiming XueCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.ORCID 0009-0008-7858-8656
Yongxing AiCollege of Animal Science, Jilin University, Changchun 130062, China.ORCID 0000-0001-5212-3609
Jing WangTechnical Innovation Laboratory for Research and Development of Economic Plants and Edible and Medicinal Fungi in Cold Regions of Jilin Province, Changchun Normal University, Changchun 130032, China.
Meizhu ZhengCentral Laboratory, Changchun Normal University, Changchun 130032, China.
Dongfang ShiCentral Laboratory, Changchun Normal University, Changchun 130032, China.

Funding

Natural Science Foundation of Jilin Province, China 20250601064R
6 · The paper itself

Abstract

Paeoniflorin (PF), a monomeric compound extracted from the dry roots of

Indexed as

Brain-Derived Neurotrophic FactorGlucosidesMonoterpenesParkinson DiseasePhosphatidylinositol 3-KinasesProteomicsSignal TransductionAnimalsApoptosisCyclic AMP Response Element-Binding ProteinGlycosidesMaleMiceMice, Inbred C57BLNeuroprotective AgentsOxidative StressBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinGlucosidesGlycosidesMonoterpenesNeuroprotective AgentspeoniflorinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBDNF/CREB signaling pathwaypaeoniflorinParkinson’s diseasePI3K/AKT signaling pathwayproteomics

Identifiers

PMID40650274
PMCPMC12249528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.