Evidence map›Paper›PMID 40650279›Full record

ArticleInternational journal of molecular sciences2025

High Prevalence of

Thaís Barbosa Ferreira Sant'Anna, Mariana Leonardo Terra, Jose Junior França de Barros, Leonardo Alexandre de Souza Ruivo, Arlete Fernandes, Maria Dirlei Ferreira de Souza Begnami, Vera Lucia Nunes Pannain, Antônio Hugo José Fróes Marques Campos, Otacilio da Cruz Moreira, Natalia Motta de Araujo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thaís Barbosa Ferreira Sant'AnnaLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0003-2837-4402
Mariana Leonardo TerraLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0009-0009-0979-9481
Jose Junior França de BarrosLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-4288-8680
Leonardo Alexandre de Souza RuivoLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Arlete FernandesDepartment of Pathology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
Maria Dirlei Ferreira de Souza BegnamiDepartment of Anatomic Pathology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
Vera Lucia Nunes PannainDepartment of Pathology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Brazil.
Antônio Hugo José Fróes Marques CamposA.C.Camargo Biobank, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
Otacilio da Cruz MoreiraLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-5340-8697
Natalia Motta de AraujoLaboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0001-9037-1304

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309649/2022-6Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.585/2024
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide, but its molecular drivers remain underexplored in Latin American populations. This study investigated the prevalence, co-occurrence, and tissue distribution of somatic mutations in the

Indexed as

beta CateninCarcinoma, HepatocellularLiver NeoplasmsMutationTelomeraseAdultAgedBiomarkers, TumorBrazilEarly Detection of CancerFemaleHumansMaleMiddle AgedPrevalencePromoter Regions, Geneticbeta CateninBiomarkers, TumorCTNNB1 protein, humanTelomeraseTERT protein, humangene expression analysisLatin Americaliver carcinogenesismutation profilingtelomerase activationtumour biomarkersviral hepatitisβ-catenin signalling

Identifiers

PMID40650279
PMCPMC12249768

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.