Observational studyAnnals of medicine2025
Clinical utility of the Platelet-to-neutrophil ratio in differentiating sepsis from neonatal pneumonia: an observational study.
Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Letter to the editor regarding: 'clinical utility of the platelet-to-neutrophil ratio in differentiating sepsis from neonatal pneumonia: an observational study'.Annals of medicine · 2026Article
- Prognostic value of combined platelet and fibrinogen levels on mortality in pediatric patients with sepsis.Annals of medicine · 2026Article
- Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Hematologic Inflammatory Indices Predict Mortality in Surgical Necrotizing Enterocolitis Among Premature Infants.Children (Basel, Switzerland) · 2026Article
- Platelet-to-neutrophil ratio and in-hospital mortality in pneumonia patients receiving glucocorticoid therapy: a multicenter retrospective cohort study.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn some cases, neonates with pneumonia can develop sepsis. The timely and accurate diagnosis of sepsis due to neonatal pneumonia poses a challenge for many clinicians. Therefore, this study aimed to evaluate the potential of the platelet-to-neutrophil ratio (PNR), as an early biomarker for clinically differentiating neonatal sepsis among pneumonia cases.
methodsWe performed a cross-sectional analysis of clinical and laboratory data collected from 1,103 patients with neonatal pneumonia [773 with pneumonia and 330 with pneumonia and sepsis (PS)].
resultsThe PS group had a lower PNR than the pneumonia group. Further analysis revealed that the incidence of PS was significantly higher in the low PNR group than in the high PNR group (43.9% vs. 15.9%,
conclusionsPNR can serve as an early biomarker for differentiating neonatal sepsis among pneumonia cases. Despite its potential, the PNR requires validation in multicenter studies.
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