ArticleThe Journal of clinical endocrinology and metabolism2025
Impact of Abdominal and Thigh Intermuscular Adipose Tissue on Glucose and Cardiometabolic Risk in Adults With Obesity.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Spatial transcriptomics maps distinct signatures of human intermuscular adipose expansion in mice.medRxiv : the preprint server for health sciences · 2026Article
- From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis.Current issues in molecular biology · 2026Review
- Intramuscular adipose tissue: from progenitor to pathology.American journal of physiology. Cell physiology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
Abstract
contextIntermuscular adipose tissue (IMAT) at different anatomical locations may exert distinct effects on cardiometabolic risk.
objectiveThe present study investigated the relationships of abdominal and mid-thigh IMAT with glucose homeostasis and cardiometabolic risk in adults with overweight or obesity.
designMulticenter cross-sectional study.
settingOutpatient clinic.
participantsOne hundred eighty-nine adults (50% women; age: 46.8 ± 6.3 years) with overweight or obesity (body mass index: 32.9 ± 3.5 kg/m2).
main outcome measuresIMAT content in abdominal and mid-thigh regions was measured by magnetic resonance imaging. Mean glucose levels were monitored over 24 hours during 14 days using continuous glucose monitoring devices. We computed a cardiometabolic risk score including fasting high-density lipoprotein cholesterol, triglycerides, glucose, waist circumference, and systolic and diastolic blood pressure.
resultsNo associations were identified between abdominal IMAT and glucose homeostasis or cardiometabolic risk (all P > .05). In contrast, a positive association of mid-thigh IMAT with 24-hour (β = 0.226; P = .007), diurnal (β = 0.224; P = .008), and nocturnal mean glucose levels (β = 0.233; P = .006) as well as with cardiometabolic risk score (β = 0.324; P < .001) was observed. Participants with greater accumulation of IMAT in the mid-thigh compared to the abdominal region exhibited significantly higher mean glucose levels and cardiometabolic risk (all P < .005).
conclusionThese findings emphasize the importance of distinguishing between adipose tissue depots when evaluating cardiometabolic risk, as specific accumulation patterns-particularly in the mid-thigh region-may significantly influence individual risk profiles.
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