ArticleProbiotics and antimicrobial proteins2026
Innovative Hydrogel Formulation Combining Phycocyanin and Probiotic for Enhancing Skin Regeneration and Accelerated Wound Healing: A Preclinical Investigation in Wistar Rats.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Human Derived Exosome Injections (ASCE+ vs. CELLEXOSOME) Enhance Collagen Remodeling and Angiogenesis in Intact Skin: A Comparative Experimental Study.Journal of cosmetic dermatology · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Skin repair is a global concern that requires multifunctional wound healing platforms that accelerate healing and shield the wound from external contamination. Phycocyanin (C-PC) is a natural protein that shows favorable characteristics for skin repair. The present study aims to investigate the synergistic wound healing potential of probiotic Pediococcus pentosaceus and C-PC hydrogel formulation. C-PC whey protein nanofibrils (WPINF) were first prepared and evaluated for particle size, % entrapment efficiency, and zeta potential. Selected WPINF was used to prepare several hydrogel formulations which were further evaluated for physical properties and in vitro C-PC release. Formulation with acceptable physical properties and C-PC release was studied for oxidative stress markers, antioxidant biomarkers, and wound healing effect in animal models. WPINF had acceptable particle size (26.59-153.5 nm), % EE (65.76-95.98%), and zeta potential (22.3-26.1 mV). The developed hydrogels exhibited neutral pH values (6.97-7.10), optimal spreadability (5.60-7.50 cm), and viscosity (123-209 Pa). HEC-based hydrogel (F1) showed superior C-PC release which was found to follow Higuchi diffusion. In vivo, hydrogel formulations (with and without probiotic) showed significantly reduced oxidative stress markers, with MDA reduced by 54.76-98.58% and antioxidant biomarkers (GSH and TAC) ensuring successful delivery of therapeutic compounds. Histological analysis showed improved re-epithelialization, reduced inflammation, and well-formed granulation tissue in treated groups, with probiotic-C-PC group demonstrating additional immunomodulatory effects. The study highlights promising potential of C-PC-probiotic hydrogels as a safe and effective biotherapeutics for wound healing, supporting their advancement into further clinical investigations to validate their efficacy in humans.
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