ArticleCerebellum (London, England)2025
FDG-PET in Autoimmune Cerebellar Ataxia: Clinical Correlation and Diagnostic Superiority Over MRI.
Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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6 authors.
Funding
Abstract
backgroundBrain magnetic resonance imaging (MRI) often appears normal in patients with autoimmune cerebellar ataxia (ACA), whereas case studies indicate [
methods55 ACA patients and 28 age and sex-matched healthy controls were included. PET results were evaluated using both visual analysis and voxel-based analysis.
resultsBefore immunotherapy, FDG-PET of ACA patients typically exhibited widespread hypermetabolism, while post-treatment scans showed cerebellar hypometabolism compared to healthy controls. Patients with encephalopathy were more likely to show abnormal metabolic activity in the cerebral cortex or hippocampus. Abnormal metabolic activity in the basal ganglia was more common in patients with extrapyramidal symptoms. Relative vermis hypermetabolism was observed in 40% of patients (22/55) and was significantly associated with a lower cerebrospinal fluid white blood cell count, higher cerebellar atrophy ratio, and cerebellar hypometabolism. Overall, the sensitivity of FDG-PET (85.5%) was significantly higher than that of MRI (39.1%, p < 0.001).
conclusionOur findings demonstrate that FDG-PET is more sensitive than MRI for detecting metabolic abnormalities in ACA patients. The metabolic differences between the cerebellar vermis and the hemispheres may suggest the vulnerability of the vermis in ACA. It also provides valuable clinical correlations, identifying patterns of hyper- and hypometabolism that align with specific neurological presentations.
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