ArticleUnited European gastroenterology journal2025
Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare.
Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The Israeli IBD Research Nucleus: collaborative advancements in Israeli IBD research.Therapeutic advances in gastroenterology · 2026Review
- Microbial metabolic memory in inflammatory bowel disease: microbiota-derived metabolites, host-microbe reprogramming, and relapse susceptibility.Frontiers in microbiology · 2026Review
- Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare.United European gastroenterology journal · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundMetabolites are key mediators of various physiological functions. However, there is a lack of data linking their levels to future Crohn's Disease (CD) flares.
objectiveWe aimed to identify systemic and gut metabolic changes that precede flare and generate metabolite-based indexes that predict flare using a test cohort, with validation using an independent cohort.
methodsWe analyzed serum and fecal metabolomes in a prospective cohort of patients with quiescent Crohn's Disease monitored until a clinical flare or the end of the study follow-up.
resultsWe identified specific metabolic changes in pre-flare samples of Crohn's Disease patients and developed prediction models for a subsequent flare using serum and fecal metabolic signatures. Among the fecal metabolites linked to future flares, metabolite classification indicated significantly fewer fatty acids and more carbohydrates in pre-flare samples of patients that eventually flared. Serum metabolites linked with future flares included reduced levels of two Krebs cycle ketogenic derivatives (3-hydroxybutyrate and acetoacetate) and higher urate in pre-flare samples. The predictions based on fecal metabolomics were validated in an independent Crohn's Disease cohort with a similar design. Higher urate levels in the serum metabolomics of the test cohort led us to develop a clinical blood-based index composed of normalized urate-to-creatinine ratio together with CRP [urate/creatinine ratio+log2 (CRP)], which was predictive of flare in the validation cohort 2.
conclusionsMetabolites linked to future flares can provide insight into mechanisms prompting the transition from quiescent to inflammatory Crohn's Disease states and may help identify those at risk for a clinical flare.
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Registered trials
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