Evidence mapPaperPMID 40650962Full record

ReviewRegenerative medicine2025

Developing stem cells for corneal disease: recent developments and future perspectives.

Ansu Ann John, Hooman Ahmadzadeh, Alfonso L Sabater

Abstract readReview
In one paragraph

Review in Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ansu Ann JohnCorneal Innovation Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Hooman AhmadzadehCorneal Innovation Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Alfonso L SabaterCorneal Innovation Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell-based regenerative therapies have revolutionized ocular medicine, offering unprecedented potential to restore vision and repair damaged corneal tissues. Recent advancements have been driven by the growing demand to overcome corneal donor shortages and the complications associated with corneal transplantation. This paper provides a comprehensive review of clinical trials and regulatory approvals over the past seven years, categorized by target disease. Despite remarkable progress, significant challenges remain in ensuring safety, efficacy, and economic viability, necessitating rigorous characterization, global standardization, and ethical considerations. Future directions include leveraging gene-editing technologies, personalized medicine, and integrated regenerative approaches to optimize therapeutic outcomes.

Indexed as

Corneal DiseasesStem CellsStem Cell TransplantationAnimalsClinical Trials as TopicCorneal TransplantationGene EditingHumansRegenerative MedicineAdult corneal stem cell nichecell therapycorneaeyeiPSCregenerative medicinetransplantation

Identifiers

PMID40650962
PMCPMC12270089

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.