ArticleSurgery2025
Impaired contractile response of human peripheral arterioles to angiotensin II after cardiopulmonary bypass.
Article in Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
introductionVasoplegia is a well-established risk after cardiopulmonary bypass. Angiotensin II is a polypeptide integral to blood pressure and intravascular volume regulation, yet limited evidence explores angiotensin II in post-cardiopulmonary bypass vasoplegia. This study aims to investigate microvascular functional and mechanistic changes to angiotensin II response after cardiopulmonary bypass.
methodsSkeletal muscle samples were collected from the left internal mammary bed before and after cardiopulmonary bypass in patients undergoing cardiac surgery. Skeletal muscle arterioles were dissected and mounted on microvessel arrays, and internal diameter changes in response to angiotensin II were noted by videomicroscopy. Paired skeletal muscle tissue was sent for deep RNA sequencing per third-party company protocol, and angiotensin II type 1 and type2 receptor expression was quantified by immunoblotting.
resultsMicrovascular constriction to angiotensin II in microvessels isolated from skeletal muscle (n = 7) was significantly attenuated in post-cardiopulmonary bypass vessels (P < .05 at 10 DISCUSSION: These novel findings demonstrate a significant decrease in functional microvascular response to angiotensin II after cardiopulmonary bypass, which may explain postoperative vasoplegia and blood pressure dysregulation. Although there were no changes in angiotensin II receptor expression, changes in G-protein-related signaling may explain this diminished response.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.