ArticleScientific reports2025
Probing the microRNA landscape in cadmium chloride induced renal toxicity through an in silico approach.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Post-pubertal Susceptibility to Cadmium-Induced Cardiac Injury: Role of Metallothionein, Antioxidant Defense, and Endocrine Modulation.Cardiovascular toxicology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium chloride (CdCl₂), a highly toxic environmental pollutant, significantly impacts kidney health, particularly in the proximal tubular cells, where it induces oxidative stress and lipid peroxidation. The specific mechanisms underlying cadmium toxicity remain unclear. It is hypothesized that it is mediated by microRNAs (miRNAs). These non-coding RNAs regulate gene expression by promoting mRNA degradation and translational repression. In this study, microarray data from HK-2 cells exposed to CdCl₂ was analyzed, revealing increased oxidative stress and disrupted mitochondrial function. The prolonged cadmium exposure disrupted gene expression and induced persistent toxicity. Notably, six miRNAs predominantly modulated the hub genes. A molecular interaction study of miRNA-mRNA duplexes indicated a strong interaction with the argonaute (AGO) protein of the RNA-induced silencing complex (RISC), suggesting that miRNA-mediated gene silencing plays a crucial role in cadmium-induced renal damage. These findings highlight the critical role of miRNAs in modulating cadmium toxicity and suggest their potential as biomarkers for cadmium-induced renal dysfunction.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.