Evidence map›Paper›PMID 40652159›Full record

ArticleBrain imaging and behavior2025

Structural connectivity of hippocampus is not altered in patients with type 2 diabetes and without peripheral microangiopathy.

Lian Liu, Ke Xu, Qian Luo, TingTing Shen, Mei Kang, MingMing Ma, YuFan Wang, Fang Fang

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Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Lian Liu *Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Ke Xu *Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Qian LuoDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
TingTing ShenDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Mei KangClinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
MingMing MaDepartment of Ophthalmology, National Clinical Research Center for Eye Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
YuFan WangDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. yyffwang@sina.com.
Fang FangDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. fang.fang@shgh.cn.

Funding

National Natural Science Foundation of China 81900813Shanghai Hospital Development Center 2020CR4013
6 · The paper itself

Abstract

Functional hyper-connectivity in hippocampus has been recently observed in patients with an early stage of type 2 diabetes, however, the structural connectivity between hippocampus and other regions of the brain and its effects on neuropsychological performance are still unknown. Participants (82 patients with type 2 diabetes and without peripheral microvascular complications; 75 healthy controls) underwent detailed cognitive assessment and diffusion MRI. Probabilistic tractography based on a multifiber model was performed to investigate the fiber connections between hippocampus and other regions of the brain. The differences in hippocampal connectivity between groups were compared with age, sex, body mass index and education as covariates. The association between hippocampal connectivity and cognitive performances in patients with diabetes were further investigated. Patients had lower Stroop Accuracy and longer Stroop Reaction Time compared with age-, sex-, education-matched controls. Although lower hippocampal connectivities to widespread brain regions were observed in diabetic group, there were no statistical differences after FDR adjustment. Moreover, the strength of fiber connections was not associated with any cognitive performance in patients with diabetes. Taken together, worse executive function was observed in patients with an early stage of type 2 diabetes. However, it might not be related to hippocampal fiber connectivity. These findings suggested that structural connectivity in hippocampus was not an early predictor for diabetes-associated cognitive decrements.

Indexed as

Diabetes Mellitus, Type 2HippocampusAgedBrainCognitionDiffusion Tensor ImagingExecutive FunctionFemaleHumansMaleMiddle AgedNeural PathwaysNeuropsychological TestsDiabetes-associated cognitive decrementsDiffusion magnetic resonanceHippocampusMicrovascular complicationType 2 diabetes

Identifiers

PMID40652159

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.