ReviewJournal of medical case reports2025
Radiation-induced temporal lobe necrosis in a nasopharyngeal cancer patient after external beam radiotherapy: a case report and review of literature.
Review in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Challenging Differential Diagnosis Between Brain Radionecrosis and Recurrent Metastatic Disease, with Temporary Clinical/Radiological Response to Bevacizumab and Later Imaging Suspicious for Oligoprogression.Life (Basel, Switzerland) · 2026Article
- Association of neurite orientation dispersion and density imaging with cognitive impairment in nasopharyngeal carcinoma patients with radiation-induced temporal lobe injury.Frontiers in human neuroscience · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNasopharyngeal carcinoma is considered rare worldwide. The treatment of nasopharyngeal carcinoma primarily relies on radiotherapy, as the tumor cells in NPC exhibit radiosensitivity. However, excessive dosage can result in a delayed reaction that affects the healthy surrounding tissues, including the central nervous system, causing brain radionecrosis, a rare yet severe condition, which can develop approximately 6-12 months after radiation as a significant complication. The majority of studies on brain radionecrosis have been conducted in China, where nasopharyngeal carcinoma is most prevalent. However, to the best of our knowledge, this is the first reported case of brain radionecrosis following radiotherapy for nasopharyngeal carcinoma in our region, which was diagnosed using magnetic resonance spectroscopy. CASE PRESENTATION: This case report describes a 49-year-old Arab male who presented with memory loss, expressive aphasia, and delirium 5 months after undergoing radiotherapy with a total radiation dose of 66 Gray for nasopharyngeal carcinoma (NPC). Magnetic resonance imaging with magnetic resonance spectroscopy revealed the presence of focal lesions in the left temporal lobe with accompanying brain edema indicative of radionecrosis.
conclusionIt is imperative to consider the possibility of brain radionecrosis in patients who have previously received radiation therapy for head and neck cancers, particularly nasopharyngeal carcinoma. Early detection of brain radionecrosis is essential, and diagnostic imaging should be performed regularly during follow-up using magnetic resonance imaging and magnetic resonance spectroscopy. The primary objective of treatment is to alleviate symptoms through medical and/or surgical interventions.
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