ArticleAnnals of medicine2025
Inflammatory indices AISI and SIRI in atherosclerosis risk stratification: validation across community and intensive care populations.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Comparison of Novel Systemic Inflammatory Indices for Identification of Left Ventricular Hypertrophy in Hypertensive Patients: A Large-Scale Cross-Sectional Study in China.Journal of cardiovascular development and disease · 2026Article
- Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- A machine learning model based on routine blood-derived indices for early arterial stiffness prediction in the community.Lipids in health and disease · 2026Article
- Joint association of systemic inflammatory response index and thromboelastography maximum amplitude with the risk of early atherosclerosis in patients with rheumatoid arthritis.Clinical and experimental medicine · 2026Article
- Association of the hs-CRP-TyG index with coronary artery disease risk and angiographic severity: a retrospective comparative study with the TyG index.Frontiers in endocrinology · 2026Article
- Evaluation of novel inflammatory biomarkers in overweight, obese, and morbidly obese children: a cross-sectional study.Frontiers in endocrinology · 2026Article
- A Body Shape Index mediates the associations of geriatric nutritional risk index with activities of daily living disability in an older rural population in Guangxi, China.Frontiers in public health · 2026Article
- Composite inflammatory biomarkers for predicting vascular crisis after finger replantation: a two-center retrospective study identifying a promising inflammatory biomarker and its multidimensional evaluation.Frontiers in immunology · 2026Article
- Comparative value of novel inflammatory indices in predicting incident carotid atherosclerosis: SIRI outperforms other markers in a general population.Frontiers in cardiovascular medicine · 2026Article
- Associations Between Systemic Immunity Inflammation Index, Aggregate Index of Systemic Inflammation, and Hospital Acquired Otitis Media in Children Aged ≤12 years with Bacterial Pneumonia.Infection and drug resistance · 2026Article
- Associations of Systemic Inflammatory Response Index (SIRI) and Systemic Inflammatory Index (SII) with Cerebral Atherosclerosis.Journal of inflammation research · 2026Article
- Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.Lipids in health and disease · 2025Article
- The predictivity of hematological parameters and related inflammatory biomarkers of male subjects with chronic polysubstance use disorder.Brain, behavior, & immunity - health · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundSystemic inflammation plays a key role in atherosclerosis development. This study evaluated the predictive performance of two composite inflammatory indices-the Aggregate Index of Systemic Inflammation (AISI) and the Systemic Inflammation Response Index (SIRI)-across community and intensive care populations. The Systemic Immune-Inflammation Index (SII) was also assessed in univariate analysis.
methodsData were obtained from a health examination cohort (
resultsSIRI was consistently associated with atherosclerosis in both cohorts and showed stronger predictive power in men and individuals with metabolic syndrome (
conclusionSIRI is a robust and consistent predictor of atherosclerosis risk in diverse populations, supporting its utility in routine health assessments and personalized screening. In contrast, AISI's predictive value is population-dependent. These results support the use of SIRI in personalized screening strategies and suggest its potential utility in routine health assessments.
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