Evidence map›Paper›PMID 40653598›Full record

ArticleActa neuropsychiatrica2025

Association between fibroblast growth factor 19 and depressive symptoms: the moderating role of smoking.

Siyuan Li, Lingling Chen, Mingwei Ma, Yueling Hu, Fan Wang, Xingguang Luo, Yu-Hsin Chen, Hongke Gao, Yulin Ren, Weiming Hu and 6 more

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In one paragraph

Article in Acta neuropsychiatrica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Siyuan LiSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Lingling ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Mingwei MaSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yueling HuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Fan WangBeijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yu-Hsin ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Hongke GaoSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yulin RenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Weiming HuThe Third Hospital of Quzhou, Quzhou, Zhejiang, China.
Yimin KangPsychosomatic Medicine Research Division, Inner Mongolia Medical University, Hohhot, China.
Wei WangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Li ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Xiaokun LiSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.
Yanlong LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0001-8733-8028
Junnan WuDepartment of Pharmacy, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to examine the relationship between fibroblast growth factor 19 (FGF19) and depressive symptoms, measured by Beck's Depression Inventory (BDI) scores and investigate the moderating role of smoking.

methodsThis study involved 156 Chinese adult males (78 smokers and 78 non-smokers) from September 2014 to January 2016. The severity of depressive symptoms was evaluated using the BDI scores. Spearman rank correlation analyses were used to investigate the relationship between cerebrospinal fluid (CSF) FGF19 levels and BDI scores. Additionally, moderation and simple slope analyses were applied to assess the moderating effect of smoking on the relationship between the two.

resultsFGF19 levels were significantly associated with BDI scores across all participants (

conclusionThese results highlight the potential role of FGF19 in individuals at risk for presence of or further development of depressive symptoms and underscore the importance of considering smoking status when examining this association.

Indexed as

DepressionFibroblast Growth FactorsSmokingAdultChinaHumansMaleMiddle AgedPsychiatric Status Rating ScalesYoung AdultFGF19 protein, humanFibroblast Growth FactorsBeck’s Depression Inventory scorescerebrospinal fluiddepressive symptomsFibroblast growth factor 19smoking

Identifiers

PMID40653598
PMCPMC13130274

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.