ArticleEuropean journal of neurology2025
The Impact of Frailty on Functional Outcome in Neurointensive Care Patients.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Target trial emulation of early acetaminophen use and mortality in critically ill stroke patients.Scientific reports · 2026Article
- Transitions and determinants of ICU-acquired frailty after critical illness: A multicenter cohort study using a multistate Markov model.Annals of intensive care · 2026Article
- The Impact of Frailty on Functional Outcome in Neurointensive Care Patients.European journal of neurology · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty, defined as an age-related syndrome of multidimensional physiological decline, may serve as a valuable marker to identify brain-injured patients who are less likely to benefit from aggressive treatment, thus avoiding unnecessary interventions. Here we aimed to evaluate the predictive value of the Clinical Frailty Scale (CFS) score for functional outcome.
methodsThis retrospective study included 1008 patients admitted to the neurological intensive care unit (ICU), with ischemic and hemorrhagic stroke (subarachnoid hemorrhage, SAH and intracerebral hemorrhage, ICH), and traumatic brain injury (TBI). Outcome was evaluated with the modified Rankin Scale (mRS) at ICU discharge. Correlations and univariate analyses identified factors linked to higher CFS levels, while multivariable logistic regression evaluated CFS's potential to predict poor outcome (mRS ≥ 4).
resultsPatients were admitted with ischemic stroke (n = 256, 25%), hemorrhagic stroke (n = 516, 51%) or TBI (n = 236, 23%) and the mean age was 66 years (IQR, 54-77). All disease severity grades were included, with a median GCS of 14 (9-15) at admission. The median premorbid CFS was 2 (1-3) with 9.2% of patients classified as frail (CFS ≥ 5). In multivariable analysis, CFS ≥ 5 was independently associated with poor outcome (adjOR [95% CI] 2.83 [1.50-5.33], p = 0.001). In a subgroup of patients aged ≥ 65 years (n = 532, 53%), a CFS-score of ≥ 5 was associated with poor outcome (adjOR [95% CI] 2.51 [1.24-5.09], p = 0.011), whereas age itself was not associated with poor outcome (p = 0.095).
conclusionsFrailty as measured by the CFS remained a significant predictor of outcome, whereas age alone was not associated with poor outcome in patients aged ≥ 65 years.
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