Evidence map›Paper›PMID 40654202›Full record

ArticleJournal of cosmetic dermatology2025

Enhancing Skin Rejuvenation: Using of Engineered Exosome Content Treated With Oleuropein and Fe

Naeimeh Safavizadeh, Zahra Noormohammadi, Mohammad Zaefizadeh, Kazem Nejati-Koshki

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Naeimeh SafavizadehDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0002-8866-3399
Zahra NoormohammadiDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0003-3890-9001
Mohammad ZaefizadehDepartment of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran.ORCID https://orcid.org/0000-0002-4930-6065
Kazem Nejati-KoshkiPharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.ORCID https://orcid.org/0000-0002-1777-5924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin aging, which is affected by intrinsic and extrinsic factors, leads to reduced elastin, collagen, and hydration levels.

aimsThis study aimed to utilize modified exosomal content with treated Oleuropein and Fe MATERIAL &

methodsFe

resultsThe results showed that the expression of IGF1, IGF1R, COL1A1, ELN, and EGF genes was significantly increased with Oleuropein (500 μg/mL) and Fe

conclusionsExosomes can increase gene expression and reduce microRNAs associated with skin antiaging. Using modified exosomal content treated with Oleuropein and Fe

Indexed as

ExosomesIridoidsRejuvenationSkin AgingCell LineCollagen Type I, alpha 1 ChainFibroblastsHumansIridoid GlucosidesMesenchymal Stem CellsMicroRNAsCollagen Type I, alpha 1 ChainIridoid GlucosidesIridoidsMicroRNAsoleuropeinFe3O4@CQD/oleuropeinmicroRNAsmodified exosomal contentoleuropeinskin rejuvenation

Identifiers

PMID40654202
PMCPMC12257441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.