ArticleJournal of the American Heart Association2025
Association of Atherogenic Index of Plasma With Stroke Risk in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: The First Evidence From the China Health and Retirement Longitudinal Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose.Journal of diabetes investigation · 2026Article
- Metabolic Indices of Atherogenicity, Insulin Resistance, and Inflammation (AIP, TyG, and CTI) and the Risk of Renal Function Decline in Early-Stage CKM Syndrome: A Nationwide Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiometabolic multimorbidity in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Joint effects of dyslipidemia and the platelet count on stroke risk: Longitudinal analysis via dynamic lipid stratification in the CHARLS cohort.BMC neurology · 2026Article
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
- Emerging multidimensional biomarker system for cardiovascular-kidney-metabolic syndrome: from multi-omics integration to clinical artificial intelligence.Cardiovascular diabetology · 2026Review
- Cumulative exposure and patterns of the cholesterol-HDL-C-glucose index and risk of new-onset cardiometabolic multimorbidity: 9-year longitudinal evidence from CHARLS.Frontiers in nutrition · 2026Article
- Nonlinear and Age-Specific Associations Between Atherogenic Index of Plasma and Differential Cardiovascular Risk Profiles in US Adults.Cardiovascular therapeutics · 2026Article
- Triglyceride glucose index and atherogenic index of plasma predict rapid kidney function decline in cardiovascular-kidney-metabolic syndrome: the first longitudinal evidence from CHARLS.European journal of medical research · 2025Article
- Association of the atherogenic index of plasma with in-hospital mortality in patients with sepsis-induced coagulopathy.Lipids in health and disease · 2025Article
- Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank.Cardiovascular diabetology · 2025Article
- Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status.Cardiovascular diabetology · 2025Article
- Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors.Frontiers in nutrition · 2025Article
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4 authors.
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Abstract
backgroundThe atherogenic index of plasma (AIP) is a marker of lipids and atherosclerosis. However, its associations with stroke risk in a population with cardiovascular-kidney-metabolic (CKM) syndrome stages 0 to 3 remain unclear.
methodsThe data for this study were obtained from CHARLS (China Health and Retirement Longitudinal Study). The AIP was calculated using the formula: AIP=log10 (triglycerides/high-density lipoprotein cholesterol). The outcome of this study was stroke events. Cox regression models and restricted cubic spline were applied to investigate the relationship between AIP and stroke risk in populations with CKM syndrome stages 0 to 3.
resultsA total of 7664 participants were included in this study, with a mean age of 59.30±9.58 years, and 53.08% were women. A total of 683 (8.91%) stroke events were recorded. After fully adjusting for covariates, each 1-unit increase in AIP was associated with a 22% increase in stroke risk (hazard ratio [HR], 1.22 [95% CI, 1.10-1.34]). AIP was further categorized into quartiles. The adjusted HRs for quartile 2, quartile 3, and quartile 4 compared with quartile 1 were 1.48 (95% CI, 1.18-1.86), 1.70 (95% CI, 1.36-2.14), and 1.58 (95% CI, 1.25-2.00), respectively. Results from restricted cubic spline revealed a significant nonlinear relationship within a population with CKM syndrome stages 0 to 3 between AIP and stroke risk (threshold=1.516).
conclusionsThis study found a nonlinear association between AIP and increased stroke incidence in a population with CKM syndrome stages 0 to 3, with a threshold of 1.516. These findings indicate that AIP could serve as a potential predictor for the risk of stroke.
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