ArticleOrthopedic research and reviews2025
Correlation Analysis of Serum G-Protein-Coupled Receptor 4 and Biglycan Levels with the Severity of Intervertebral Disc Degeneration.
Article in Orthopedic research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the correlation between serum levels of G protein-coupled receptor 4 (GPR4) and Biglycan (BGN) with the severity of Intervertebral Disc Degeneration (IVDD). Methods: A total of 162 patients with IVDD treated at our hospital from August 2023 to August 2024 were included. The general information of patients was retrospectively collected. MRI was used to assess IVDD severity using the Pfirrmann grading system. Serum GPR4 and BGN levels were measured by enzyme-linked immunosorbent assay (ELISA). Multiple linear regression analysis was performed to identify risk factors for IVDD severity. Results: Significant differences in age and the proportion of diabetic patients as well as serum GPR4 and BGN were found among different Pfirrmann grades ( Conclusions: Serum GPR4 and BGN levels are identified as effective diagnostic indicators for IVDD, with serum GPR4 positively correlated but BGN negatively correlated with the severity of IVDD.
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