ArticleNeuroscience applied2025
Sex hormones and serotonin 4 receptor brain binding in men with and without major depressive disorder.
Article in Neuroscience applied, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sex-dependent serotonergic signaling across development: molecular mechanisms shaping vulnerability to neurodevelopmental and mental disorders.Frontiers in pharmacology · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex hormones may contribute to the pathophysiology of Major Depressive Disorder (MDD) through effects on the serotonergic brain system. Estradiol is associated with serotonergic neurobiology in rodent models and humans across sexes. In healthy men, we have previously observed a negative association between testosterone and serotonin 4 receptor (5-HT4R) levels, a receptor implicated in depression and a promising novel antidepressant target. Here, we investigate the associations between sex hormone levels and 5-HT4R binding in unmedicated men with MDD compared to healthy men. We used a latent variable model to evaluate the association between estradiol and testosterone, and cerebral 5-HT4R binding based on [
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