Evidence map›Paper›PMID 40654675›Full record

ArticlebioRxiv : the preprint server for biology2025

Loss of age-associated increase in m

Jenna L Libera, Junming Hu, Tuyet-Anh Nguyen, Zihan Wang, Sophie J F van der Spek, Kamryn Schult, Luke Dorrian, Jordan Majka, Katarnut Tobunluepop, Sambhavi Puri and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jenna L LiberaDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0003-1845-1742
Junming HuDepartment of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0002-6503-7491
Tuyet-Anh NguyenDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Zihan WangDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Sophie J F van der SpekDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0002-9324-9571
Kamryn SchultDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Luke DorrianDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0009-0002-1640-183X
Jordan MajkaDyno Therapeutics, Watertown, MA.
Katarnut TobunluepopDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Sambhavi PuriDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0009-0003-1991-3977
Alexander KynshovDepartment of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Nicholas M KanaanDept. of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503.ORCID 0000-0002-4362-2593
Peter T NelsonDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY.
Kate MeyerDept. of Biochemistry, Duke University, Durham, NC.ORCID 0000-0001-7197-4054
Lei HouDepartment of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Xiaoling ZhangDepartment of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0001-8237-1857
Benjamin WolozinDepartment of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0003-2068-1475

Funding

RL5: Research Education CoreP30AG072978 · BOSTON UNIVERSITY MEDICAL CAMPUS · 2025 to 2025
$3.2M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · UNIVERSITY OF KENTUCKY · 2025 to 2025
$2.8M
The role of N6-methyladenosine modified RNA in Alzheimer's diseaseR01AG080810 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 to 2025
$1.6M
APOE Genotype Mediated Effects on Alzheimer Disease Risk and MechanismsU01AG082665 · BOSTON UNIVERSITY MEDICAL CAMPUS · 2025 to 2025
$786k
Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathologyU01AG072577 · BOSTON UNIVERSITY MEDICAL CAMPUS · 2025 to 2025
$598k
NIA NIH HHS F31 AG090051NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072978NIA NIH HHS R01 AG064932NIA NIH HHS R01 AG080810NIA NIH HHS U01 AG072577NIA NIH HHS U01 AG082665NINDS NIH HHS U01 NS086659NINDS NIH HHS U54 NS115266
6 · The paper itself

Abstract

Dysregulated RNA metabolism is a significant feature of Alzheimer's disease (AD), yet how post-transcriptional RNA modifications like

Indexed as

agingAlzheimer’s diseaseGABAergic signalingN6-methyladenosine (m6A)proteostasisRNA translationtripartite synapses

Identifiers

PMID40654675
PMCPMC12247753

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.