Evidence map›Paper›PMID 40654749›Full record

ArticlebioRxiv : the preprint server for biology2025

Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology.

Viktoria Haghani, Sara Mohsen Ali, Noemi Cannizzaro, Mandar M Patil, Paula Dm Sullivan, Ammara Rehamn, Ralph Green, Roy Ben-Shalom, Janine M LaSalle, Konstantinos Zarbalis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Viktoria HaghaniDepartment of Medical Microbiology and Immunology, Genome Center, University of California, Davis. Davis, CA, USA.ORCID 0000-0002-3700-4027
Sara Mohsen AliDepartment of Pathology and Laboratory Medicine, University of California, Davis, CA 95817, USA.
Noemi CannizzaroDepartment of Pathology and Laboratory Medicine, University of California, Davis, CA 95817, USA.
Mandar M PatilMIND Institute, University of California, Davis, CA 95817, USA.
Paula Dm SullivanMIND Institute, University of California, Davis, CA 95817, USA.
Ammara RehamnMIND Institute, University of California, Davis, CA 95817, USA.
Ralph GreenDepartment of Pathology and Laboratory Medicine, University of California, Davis, CA 95817, USA.
Roy Ben-ShalomMIND Institute, University of California, Davis, CA 95817, USA.
Janine M LaSalleDepartment of Medical Microbiology and Immunology, Genome Center, University of California, Davis. Davis, CA, USA.
Konstantinos ZarbalisDepartment of Pathology and Laboratory Medicine, University of California, Davis, CA 95817, USA.

Funding

Folic Acid, B12, and Neurodevelopmental RiskR01HD107489 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RALPH GREEN, Konstantinos Zarbalis · 2022 to 2026
$2.3M
Mosaic analysis with double markers in the study of neuronal migration disordersR21MH115347 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZARBALIS, KONSTANTINOS · 2018 to 2019
$432k
NICHD NIH HHS R01 HD107489NIMH NIH HHS R21 MH115347
6 · The paper itself

Abstract

Folate is crucial for various biological processes, with deficiencies during pregnancy being linked to increased risk for neural tube defects and neurodevelopmental disorders. As a proactive measure, folic acid fortification in foods has been mandated in many countries, in addition to dietary supplementation recommendations during pregnancy. However, the risks of excess prenatal folic acid supply have yet to be fully understood. To better appreciate

Identifiers

PMID40654749
PMCPMC12248018

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.