ArticlebioRxiv : the preprint server for biology2025
IRE1α and IRE1β Protect Intestinal Epithelium and Suppress Colorectal Tumorigenesis through Distinct Mechanisms.
Ruishu Deng, Miao Wang, Thanyarat Promlek, Clementine Druelle-Cedano, Rabi Murad, Nicholas O Davidson, Randal J Kaufman
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Ruishu DengDegenerative Diseases Program, Center for Genetic Disorders and Aging Research, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.
Miao WangDegenerative Diseases Program, Center for Genetic Disorders and Aging Research, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.
Thanyarat PromlekDegenerative Diseases Program, Center for Genetic Disorders and Aging Research, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.
Clementine Druelle-CedanoDegenerative Diseases Program, Center for Genetic Disorders and Aging Research, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.
Rabi MuradBioinformatics Core, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.
Nicholas O DavidsonWashington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Randal J KaufmanDegenerative Diseases Program, Center for Genetic Disorders and Aging Research, SBP Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla CA 92037, USA.ORCID 0000-0003-4277-316X Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MTriglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6MToward Safer Gene Therapy for Hemophilia AP01HL160472 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Roland W. Herzog · 2022 to 2026
$15.1MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8MRole of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2MModifiers of Proinsulin Influence T2D SusceptibilityR24DK110973 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ARVAN, PETER, ITKIN-ANSARI, PAMELA ROSE · 2016 to 2019
$4.1MImpaired VLDL secretion, progression and reversal of hepatic fibrogenesisR01DK119437 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2019 to 2026
$3.8MER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinomaR01CA198103 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2016 to 2020
$3.4MHomeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid MetabolismR01DK103185 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2015 to 2019
$2.9MMechanism of ER Protein Misfolding-Induced Mitochondrial DysfunctionR01DK113171 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2017 to 2020
$2.5MIntestinal Resection Associated Liver Injury and FibrosisR01DK128169 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O., DING, LI · 2021 to 2024
$2.3MNCI NIH HHS P01 CA281819NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA198103NHLBI NIH HHS P01 HL151328NHLBI NIH HHS P01 HL160472NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK103185NIDDK NIH HHS R01 DK113171NIDDK NIH HHS R01 DK119437NIDDK NIH HHS R01 DK128169NIDDK NIH HHS R24 DK110973
6 · The paper itselfAbstract
Intestinal epithelial cells (IECs) uniquely express two IRE1 paralogues, IRE1α and IRE1β, whose roles in intestinal physiology are incompletely understood. We examined the individual and cooperative functions of IRE1α and IRE1β in IECs using mice using intestine-specific deletion of
Indexed as
colitiscolon cancerER stressIntestinal homeostasisIntestinal stem cellIRE1α/ERN1IRE1β/ERN2XBP1
Identifiers
PMID40654814
PMCPMC12247944
What Socratic holds
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