Evidence map›Paper›PMID 40654887›Full record

ArticlebioRxiv : the preprint server for biology2025

Multiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes.

Lirong Zheng, Yixiao Yan, Bingxin Zhou, Jormay Lim, Dongqing Shi, Bobae An, BumJin Ko, Emily Klyder, Sethuramasundaram Pitchiaya, Denise J Cai and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lirong ZhengDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Yixiao YanDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Bingxin ZhouDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.
Jormay LimDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Dongqing ShiDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Bobae AnMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
BumJin KoNash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emily KlyderDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Sethuramasundaram PitchiayaDepartments of Urology and Pathology, Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, USA.
Denise J CaiNash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Edward S BoydenMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Donglai WeiDepartment of Computer Science, Boston College, Boston, MA, USA.
Pietro LiòDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.
Changyang LinghuDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.

Funding

Circuit Mechanisms of Retrospective Memory-LinkingR01MH120162 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Denise Jade Cai · 2020 to 2026
$3.9M
Multidisciplinary Research Training in Sleep ScienceT32HL160511 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INDU A AYAPPA, ANDREW W VARGA · 2023 to 2026
$1.5M
Temporally scalable recording of brain-wide single-cell physiologyDP2MH140133 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINGHU, CHANGYANG · 2024 to 2024
$1.3M
NHLBI NIH HHS T32 HL160511NIMH NIH HHS DP2 MH140133NIMH NIH HHS R01 MH120162
6 · The paper itself

Abstract

Gene expression is constantly regulated by gene regulatory networks that consist of multiple regulatory components to mediate cellular functions. An ideal tool for analyzing gene regulation processes would provide simultaneous measurements of the dynamics of many components in the gene regulatory network, but existing methodologies fall short of simultaneously tracking the dynamics of components over long periods of time. Here, we present CytoTape-a genetically encoded, modular, and scalable analog recorder for continuous, multiplexed

Identifiers

PMID40654887
PMCPMC12247689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.