Evidence map›Paper›PMID 40654932›Full record

ArticlebioRxiv : the preprint server for biology2025

Disease-associated loci share properties with response eQTLs under common environmental exposures.

Wenhe Lin, Mingyuan Li, Olivia Allen, Jonathan Burnett, Joshua M Popp, Matthew Stephens, Alexis Battle, Yoav Gilad

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenhe LinDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Mingyuan LiDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Olivia AllenDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA.
Jonathan BurnettDepartment of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA.
Joshua M PoppDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Matthew StephensDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-5397-9257
Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Yoav GiladDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-8284-8926

Funding

Characterizing and Understanding Variation in Gene Regulatory Mechanisms Within and Between Species'R35GM131726 · NIGMS · UNIVERSITY OF CHICAGO · PI Yoav Gilad · 2019 to 2026
$3.7M
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1M
NIGMS NIH HHS R35 GM131726NIGMS NIH HHS R35 GM139580
6 · The paper itself

Abstract

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures

Identifiers

PMID40654932
PMCPMC12247639

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.