Evidence map›Paper›PMID 40655027›Full record

ArticlebioRxiv : the preprint server for biology2025

Macrophage Migration Inhibitory Factor Suppresses Natural Killer Cell Response and Promotes Hypoimmunogenic Stem Cell Engraftment Following Spinal Cord Injury.

Shenglan Li, Yiyan Zheng, Haipeng Xue, Haiwei Zhang, Jiayun Wu, Xiaohui Chen, Miguel Perez Bouza, Samantha Yi, Hongxia Zhou, Xugang Xia and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Shenglan LiThe Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Yiyan ZhengCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Haipeng XueCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Haiwei ZhangCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Jiayun WuThe Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Xiaohui ChenCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Miguel Perez BouzaCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Samantha YiCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Hongxia ZhouCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Xugang XiaCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Xianmin ZengRxCell Inc. Novato, CA 94945, USA.
Qi Lin CaoCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.
Ying LiuCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, Florida 34987, USA.ORCID 0000-0003-1875-8293

Funding

Reconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitorsR01NS110707 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YING · 2019 to 2023
$1.7M
Combinatory strategies to functional remyelination after spinal cord injuryR01NS061975 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CAO, QI LIN · 2008 to 2012
$1.6M
NINDS NIH HHS R01 NS061975NINDS NIH HHS R01 NS110707
6 · The paper itself

Abstract

Human induced pluripotent stem cells (iPSCs) offer immense potential as a source for cell therapy in spinal cord injury (SCI) and other diseases. The development of hypoimmunogenic, universal cells that could be transplanted to any recipient without requiring a matching donor, could significantly enhance their therapeutic potential and accelerate clinical translation. To create off-the-shelf hypoimmunogenic cells, we used CRISPR-Cas9 to delete B2M (HLA class I) and CIITA (master regulator of HLA class II). Double-knockout (DKO) iPSC-derived neural progenitor cells (NPCs) evaded T cell-mediated immune rejection

Indexed as

immune rejectiontransplantationUniversal stem cells

Identifiers

PMID40655027
PMCPMC12247959

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.