ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Exploring the Incidence and Risk Factors of Diabetic Nephropathy in Type 1 Diabetes: Insights from a Retrospective Cohort Study in Northwest China.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The study aimed to investigate the incidence of diabetic nephropathy (DN) and their relationship with certain risk factors in patients with type 1 diabetes (T1D) across hospitals in Gansu Province, China. Methods: There were 434 T1D patients recruited from Gansu Province, China, in the present retrospective cohort study between January 2016 and December 2024. Patients were divided into two groups: (i) patients with T1D but without DN and (ii) type 1 diabetic nephropathy (T1DN). Eligibility for T1DN patients included a T1D diagnosis coupled with urine albumin to creatinine ratio ≥ 30 mg/g. Lifetable method helped determine the cumulative T1DN incidence, and Cox regression helped analyze the associated risk factors. The correlation between predictors (eg, age, serum creatinine (Scr)), and T1DN was assessed with restricted cubic spline curves depending on Cox proportional hazards regression models. Results: The five-year cumulative incidence of T1DN was 29.89%. T1DN risk factors included diabetic ketosis/ketoacidosis (hazard ratio (HR): 1.623, 95% confidence interval (CI): 1.099-2.454, Conclusion: Younger age and lower HDL-C levels were identified as risk factors for DN in patients with T1D. Additionally, diabetic ketosis/ketoacidosis and elevated Scr levels were associated with increased DN risk. Early diagnosis and treatment of dyslipidemia are warranted in patients with T1D. Furthermore, close monitoring of patients with diabetic ketosis/ketoacidosis or high Scr levels is crucial for DN management in these patients.
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