ArticleJournal of mood and anxiety disorders2025
The association between depressive symptoms and limitations in disability domains among US adults.
Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Sleep fragmentation and heightened inflammation: A latent profile subtype predicting nine-year major depressive disorder severity in the MIDUS study.Brain, behavior, & immunity - health · 2026Article
- Machine Learning-Based Multidimensional Health Decline Prediction Framework: Data-Driven Modeling for the Middle-Aged and Elderly Population.Healthcare (Basel, Switzerland) · 2026Article
- Association Between Depressive Symptoms and Severe Vision Difficulty Among United States Adults.Cureus · 2026Article
- Associations between self-reported depression and functioning across ICF domains: a Danish population-based study.Frontiers in rehabilitation sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to evaluate the association of depressive symptoms and their severity with overall disability and disability domains, and to assess temporal changes in these associations. Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018 were analyzed. A total of 15,565 participants were included, with 1383 (8.19 %) reporting depressive symptoms. Depressive symptoms were strongly associated with overall disability (aOR = 7.82; 95 % CI = 6.27, 9.75; p < 0.001) and with six specific domains (aOR = 2.54 for hearing, 2.84 for seeing, 10.53 for concentrating, 4.42 for walking, 6.01 for dressing or bathing, and 7.36 for doing errands alone; all p < 0.001). Each unit increase in PHQ-9 score was linked to a 21 % increase in the odds of overall disability (aOR = 1.21; 95 % CI = 1.19, 1.23; p < 0.001) and to a 9 %-25 % increase in the odds of domain-specific difficulties. Both cognitive-affective (aOR = 1.35; 95 % CI = 1.30, 1.40) and somatic scores (aOR = 1.36; 95 % CI = 1.33, 1.39) were associated with overall disability and domain-specific difficulties, with each unit increase linked to 13 %-45 % higher odds. Temporal analysis indicated that depressive symptoms are linked to a higher prevalence of disability, with this association persisting and slightly increasing over time. Our findings indicated the association between depressive symptoms and disability. Future studies should further replicate our results and evaluate the mechanisms underlying this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.