ArticleFrontiers in nutrition2025
The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Introduction: This study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors. Methods: Using NHANES data (1999-2018), 2,969 eligible cancer survivors were categorized into four groups based on SII and GNRI levels. Mortality risk was assessed through unadjusted and fully adjusted Cox proportional hazards models. Results: The combination of low SII and high GNRI was associated with the lowest mortality risk (HR = 1.0, reference). In contrast, high SII and low GNRI significantly increased mortality risk (fully adjusted HR = 6.178, 95% CI: 2.669-14.299). Both unadjusted and adjusted models confirmed that high SII correlated with higher mortality, while low GNRI independently predicted poorer outcomes. Subgroup analyses revealed significant interactions between the SII-GNRI combination and gender/alcohol consumption. Discussion: The findings highlight SII and GNRI as critical predictors of all-cause mortality in cancer survivors. Their combined assessment may improve risk stratification and guide targeted clinical interventions.
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