Evidence map›Paper›PMID 40655495›Full record

ReviewIranian journal of public health2025

Efficacy of Intravenous Immunoglobulin for Patients with Recurrent Miscarriage: A Meta-Analysis.

Yan Gao, Limin Peng, Chengkun Yuan, Shanshan Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yan GaoDepartment of Obstetrical, First Affiliated Hospital, Heilongjiang University of Chines Medicine, Harbin 150001, Heilongjiang Province, China.
Limin PengDepartment of Obstetrical, First Affiliated Hospital, Heilongjiang University of Chines Medicine, Harbin 150001, Heilongjiang Province, China.
Chengkun YuanDepartment of Obstetrical, First Affiliated Hospital, Heilongjiang University of Chines Medicine, Harbin 150001, Heilongjiang Province, China.
Shanshan ZhangDepartment of Obstetrical, Beidahuang Group General Hospital, Harbin 150000, Heilongjiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to evaluate the efficacy and safety of intravenous immunoglobulin (IVIG) therapy for recurrent miscarriage (RMC) using meta-analysis. Methods: Literature from Jan 1990 to Feb 2024 was searched in PubMed, etc., using keywords such as "IVIG", "repetitive miscarriage", and "RMC". Two authors independently assessed the literature quality and risk of via Cochrane handbook, and extracted basic information and outcome indicator data. Meta-analysis was performed employing Review Manager 5.3. Results: Eleven studies were involved, comprising 842 patients, of which 391 received IVIG therapy and 451 received placebo treatment. Relative to placebo group, IVIG group had a notably higher overall live birth rate (OR=2.24, 95% CI=1.68~2.98, Z=5.51, Conclusion: IVIG can markedly increase the live birth rate, reduce the miscarriage rate, and enhance pregnancy outcomes in patients with RMC. Nevertheless, the rate of ARs with IVIG therapy is relatively high, thus large-scale, multicenter, randomized controlled trials are needed for validation.

Indexed as

Adverse reactionsIntravenous immunoglobulinMeta-analysisPregnancy outcomeRecurrent miscarriage

Identifiers

PMID40655495
PMCPMC12241738

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.