Evidence map›Paper›PMID 40655549›Full record

ArticleFrontiers in plant science2025

Plant-related quality attributes affecting FcγRIIIa binding: affinity chromatography analysis of rituximab glycovariants from

Sara Tengattini, Aurora Tini, Carla Marusic, Francesca Rinaldi, Isabella Senini, Enrica Calleri, Virginia Perez, Claudio Pisano, Marcello Donini, Caterina Temporini

Abstract read
In one paragraph

Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Plant-Based Systems for Producing Therapeutic Proteins: Current Status and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara TengattiniLaboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.
Aurora TiniLaboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.
Carla MarusicDivision of Biotechnology, ENEA Casaccia Research Center, Rome, Italy.
Francesca RinaldiLaboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.
Isabella SeniniLaboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.
Enrica CalleriLaboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.
Virginia PerezSpecial Product's Line Spa, Anagni, Italy.
Claudio PisanoSpecial Product's Line Spa, Anagni, Italy.
Marcello Donini *Division of Biotechnology, ENEA Casaccia Research Center, Rome, Italy.
Caterina Temporini *Laboratory of Pharmaceutical Analysis, Department of Drug Sciences, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibodies (mAb) produced in plants, known as plantibodies, represent a cost-effective alternative to conventional mammalian cell cultures. Glycoengineering processes are needed to alter N-glycosylation, avoiding plant-typical glycans and enabling, for anti-cancer mAbs, the production of biobetters with improved antibody-dependent cell-mediated cytotoxicity (ADCC). In this study, glycovariants of the mouse/human chimeric anti-CD20 antibody rituximab were produced in

Indexed as

affinity chromatographyantibody-dependent cell cytotoxicityFCγRIIIa receptorglycoengineeringglycosylationmonoclonal antibodiesplantibodiesrituximab

Identifiers

PMID40655549
PMCPMC12246787

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.