Evidence map›Paper›PMID 40655909›Full record

ArticleJournal of mood and anxiety disorders2024

Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program.

A Irem Sonmez, Ryan Webler, Alyssa M Krueger, Clara Godoy-Henderson, Christi Sullivan, Saydra Wilson, Sarah Olsen, Sabine Schmid, Alexander Herman, Alik Widge and 3 more

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

A Irem SonmezDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Ryan WeblerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Alyssa M KruegerDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Clara Godoy-HendersonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Christi SullivanDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Saydra WilsonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Sarah OlsenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Sabine SchmidDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Alexander HermanDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Alik WidgeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Carol PetersonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Ziad NahasDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
C Sophia AlbottDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression. Methods: Pre and post treatment PHQ-9 and IDS-SR data were collected from 181 TRD patients who received dorsolateral prefrontal cortex ( dlPFC) TMS using the Figure-8 or H1-coil. Changes in overall depression symptoms, anhedonia, and SI were analyzed using chi square tests, repeated measure ANOVAS, and linear regression for repeated measures. Results: TMS yielded changes in overall depression symptoms (PHQ-9 Cohen's Limitations: The lack of a control arm and a neuroimaging measure temper mechanistic conclusion. Conclusion: Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS.

Indexed as

AnhedoniaSuicidal ideationTranscranial magnetic stimulation (TMS)Treatment-resistant depression (TRD)

Identifiers

PMID40655909
PMCPMC12244062

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.