Evidence map›Paper›PMID 40655940›Full record

ArticleJournal of biomedical optics2025

Depth-dependent fluence compensation without

David Qin, Xinyue Huang, Timothy Sowers, Donald VanderLaan, Stanislav Emelianov

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David QinGeorgia Institute of Technology and Emory University School of Medicine, Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0001-9963-4641
Xinyue HuangGeorgia Institute of Technology and Emory University School of Medicine, Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0001-5202-3368
Timothy SowersParker H. Petit Institute for Bioengineering and Bioscience, Atlanta, Georgia, United States.ORCID 0000-0001-9293-0472
Donald VanderLaanGeorgia Institute of Technology, School of Electrical Engineering, Atlanta, Georgia, United States.
Stanislav EmelianovGeorgia Institute of Technology and Emory University School of Medicine, Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0002-7098-133X

Funding

Image-guided cancer therapy using heat activatable CAR T cellsR01EB032822 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y, KWONG, GABRIEL A · 2022 to 2025
$2.6M
NIBIB NIH HHS R01 EB032822NIH HHS 1R21NS112885
6 · The paper itself

Abstract

Significance: Compensation for depth-dependent fluence without Aim: We developed a method for estimating the effective optical attenuation coefficient of bulk tissue with composition and optical properties that are not known in advance, through combined ultrasound/photoacoustic imaging during mechanical displacement of tissue. Approach: Ultrasound/photoacoustic imaging was performed on a target embedded in biological media while applying tissue displacement to change the optical path. After compensation for geometry-dependent scattering of light from light source apertures, the change of photoacoustic amplitude against optical path length was used to estimate the effective optical attenuation coefficient. Results: Using the developed approach, the estimation of the effective optical attenuation coefficient of tissue-mimicking (milk/water) phantoms and Conclusions: Regardless of the varying geometries used for light delivery in photoacoustic imaging, it is feasible to perform ultrasound-guided photoacoustic imaging with simultaneous mechanical displacement of tissue to determine the effective optical attenuation coefficient of bulk tissue along the light path to the target.

Indexed as

Image Processing, Computer-AssistedPhotoacoustic TechniquesAnimalsBreastChickensMuscle, SkeletalPhantoms, ImagingSwineUltrasonographycompensationfluencelight attenuationphotoacousticsquantitativeultrasound

Identifiers

PMID40655940
PMCPMC12255355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.