Evidence map›Paper›PMID 40656102›Full record

ReviewNeuroscience applied2024

To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?

Virginie Tolle, Chloe Tezenas du Montcel, Julia Mattioni, Erik Schéle, Odile Viltart, Suzanne L Dickson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Virginie TolleUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Vulnerability of Psychiatric and Addictive Disorders, F-75014, Paris, France.
Chloe Tezenas du MontcelUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Vulnerability of Psychiatric and Addictive Disorders, F-75014, Paris, France.
Julia MattioniUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Vulnerability of Psychiatric and Addictive Disorders, F-75014, Paris, France.
Erik SchéleInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden.
Odile ViltartUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Vulnerability of Psychiatric and Addictive Disorders, F-75014, Paris, France.
Suzanne L DicksonInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ghrelin is an orexigenic hormone that orchestrates many diverse behaviours of relevance for feeding control. It appears to operate as a hunger hormone, organizing food intake into meals and ensuring that we seek out and consume a variety of foods. With this physiological biography, the ghrelin system, including the pathways through which it operates, has been interrogated for its role in the aetiology, pathology and treatment of eating disorders. While common obesity does not appear to be a hyperghrelinemic state, it would be difficult to completely rule out enhanced ghrelin signalling. At the other end of the body weight spectrum, it can be questioned whether patients suffering from anorexia nervosa develop ghrelin resistance and/or have high levels of LEAP2, an endogenous antagonist for GHSR, since they do not eat despite having high ghrelin levels. The purpose of this review is to outline gaps in knowledge in the ghrelin field, including in the context of eating disorders.

Indexed as

Agouti-related peptideAnorexia nervosaEating disordersGhrelinLEAP2ObesityReward system

Identifiers

PMID40656102
PMCPMC12244000

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.