Evidence map›Paper›PMID 40656109›Full record

ReviewNeuroscience applied2024

What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research.

Laura Di Lodovico, Héloise Hamelin, Lucas DeZorzi, Chloe Tezenas du Montcel, Erik Schéle, Iris Stoltenborg, Roger Adan, Suzanne Dickson, Philip Gorwood, Virginie Tolle and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Di LodovicoClinique des Maladies Mentales et de l'Encéphale, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014, Paris, France.
Héloise HamelinUniversité de Paris, INSERM, Institut de Psychiatrie et Neuroscience de Paris (IPNP), U1266, F-75014, Paris, France.
Lucas DeZorziUniversité de Lille, CNRS, UMR 9193, SCALab - Sciences Cognitives et Sciences Affectives, PsySEF Departement, U9193, F-59653, Villeneuve d'Ascq, France.
Chloe Tezenas du MontcelClinique des Maladies Mentales et de l'Encéphale, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014, Paris, France.
Erik SchéleInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, SE-405 30, Gothenburg, Sweden.
Iris StoltenborgInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, SE-405 30, Gothenburg, Sweden.
Roger AdanDepartment of Translational Neurosciences, University Medical Center Utrecht, Universiteitsweg 100, 3584, CG, Utrecht, the Netherlands.
Suzanne DicksonInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, SE-405 30, Gothenburg, Sweden.
Philip GorwoodClinique des Maladies Mentales et de l'Encéphale, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014, Paris, France.
Virginie TolleUniversité de Paris, INSERM, Institut de Psychiatrie et Neuroscience de Paris (IPNP), U1266, F-75014, Paris, France.
Odile ViltartUniversité de Paris, INSERM, Institut de Psychiatrie et Neuroscience de Paris (IPNP), U1266, F-75014, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa is a serious mental illness characterized by voluntary restriction of food intake and avoidance of high-calorie food. Anxiety, highly comorbid with anorexia nervosa, appears to be a significant, yet underexplored, factor affecting core behavioural symptoms such as food restriction and compulsive physical exercise. The aims of this review are to disentangle the influence of anxiety in food decision-making in anorexia nervosa and to offer a comprehensive model connecting the mechanisms involved. The shift from food approach to avoidance seems to be a conditioned response, underpinned by an activation of salience and fear circuitry. Altered neurotransmission (dopamine, serotonin) and neuroendocrine release (leptin, ghrelin, cortisol), aberrant neural structure activation (hyperactivation of the amygdala and hypoactivation of the insula-ventral striatum circuit) and cognitive and behavioural traits shared by anxiety and anorexia nervosa (rigidity, compulsiveness) contribute to these modifications. Animal models suggest a bidirectional relationship between food restriction and anorectic-like behaviours, strengthening yet complexifying the link between anxiety and food choice in anorexia nervosa. Therapeutic strategies focusing on anxiety and the conditioned response could contribute to restore healthy food choices and dissociate food stimuli from the anxious response elicited.

Indexed as

Animal modelsAnorexia nervosaAnxietyDecision-makingFood choicesReward

Identifiers

PMID40656109
PMCPMC12244085

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.