ArticleCancer management and research2025
Regulatory Role and Mechanism of lncRNA RNF217-AS1 in the Proliferation and Migration of Esophageal Cancer Cells.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Long non-coding RNAs: a new hope for the cervical cancer staging.Molecular biology reports · 2026Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to explore the effect of the long non-coding RNA (lncRNA) RNF217-AS1 on the proliferation and migration of esophageal cancer cells, and to uncover the molecular mechanisms through which RNF217-AS1 regulates these processes. Methods: The expression of RNF217-AS1 was measured in esophageal cancer cell lines (EC9706, Ecal09, KYSE-510, and TE-13) and immortalized esophageal epithelial HET-1 A cells using RT-qPCR. KYSE-510 cells were transfected with si-NC or si-RNF217-AS1 plasmids. Colony formation assays were used to assess cell proliferation, while migration ability was evaluated using scratch assays. A dual-luciferase reporter system was employed to verify the interaction between RNF217-AS1 and miR-377-3p. The expression of miR-377-3p and key proteins related to cell migration and epithelial-to-mesenchymal transition (EMT) were detected by RT-qPCR and Western blot. Results: RNF217-AS1 expression was significantly upregulated in esophageal cancer cells compared to HET-1 A cells (P<0.01). Downregulation of RNF217-AS1 in KYSE-510 and Eca109 cells led to a reduction in cell proliferation and migration (P<0.01). The dual-luciferase assay confirmed the interaction between RNF217-AS1 and miR-377-3p (P<0.01). miR-377-3p expression was elevated in the si-RNF217-AS1 group compared to the si-NC group (P<0.01). Furthermore, the protein levels of HOXA1, fibronectin, and FOXC2 were downregulated, while GRHL2 and E-cadherin expressions were increased in the si-RNF217-AS1 group (P<0.01). Conclusion: RNF217-AS1 is upregulated in esophageal cancer cells, and its downregulation inhibits the proliferation, migration and EMT of esophageal cancer cells by regulating the miR-377-3p/HOXA1 axis.
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