ArticleCancer management and research2025
The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic nutritional index and survival in prostate cancer: an updated systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- Improving Prognostic Prediction in Head and Neck Cancer Through a Combined Systemic Immune-Inflammation Index and Prognostic Nutritional Index Score.Current oncology (Toronto, Ont.) · 2026Article
- Combined nutritional and inflammatory risk stratification for predicting functional outcomes in acute ischemic stroke.Frontiers in nutrition · 2026Article
- Effects of neoadjuvant novel endocrine therapy combined with prostatic artery embolization on SII, PNI, and bRFS in patients with prostate cancer.American journal of translational research · 2026Article
- Pan-immune-inflammation value and prognostic nutritional index can predict the 2-year recurrence of triple-negative breast cancer patients after radical resection.Frontiers in oncology · 2026Article
- Integrating nutritional and immune-inflammation-based index predicts disease-free survival of colorectal cancer patients undergoing radical surgery.Journal of gastrointestinal oncology · 2025Article
- Clinical Utility of Monocyte-to-Lymphocyte Ratio and Prognostic Nutritional Index in Diagnosing Smear-Negative Pulmonary Tuberculosis with Negative IGRA Results.Infection and drug resistance · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammation and nutrition status were the essential factors for cancer initiation and progression. Previous studies have confirmed systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could predict the prognosis of cancer patients. The aim of this study was to evaluate the pre-treatment SII and PNI in predicting outcomes in different cancers. Methods: The retrospective study included 508 cancer cases diagnosed between June 2013 and June 2022. The pre-treatment SII and PNI were calculated from peripheral blood samples, and the cutoff value was determined by receiver operating characteristic (ROC). The association of SII, PNI with clinicopathological characters and prognosis were assessed by Cox regression and Kaplan-Meier methods. Results: The ideal preoperative SII and PNI cutoff values were 792.0 and 49.825, respectively. High SII group as well as low PNI group had worse prognosis. Patients satisfied both high SII and low PNI had the lowest overall survival (OS) rate ( Conclusion: High level of pretreatment SII may be an independent prognostic factor for cancer patients. Patients with both high SII and low PNI had the worst prognosis.
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