Trial reportWorld journal of gastroenterology2025
Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias.
Trial report in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sirolimus and gastrointestinal angiodysplasia: Can an established agent change the way gastrointestinal bleeding is managed?World journal of gastroenterology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal angiodysplasias (GIAD) causes recurrent bleeding, and current treatments have limitations. Sirolimus, a mammalian target of rapamycin inhibitor, shows promise in inhibiting abnormal angiogenesis.
aimTo evaluate the efficacy and safety of sirolimus in reducing bleeding episodes and improving clinical outcomes in patients with GIAD.
methodsWe conducted a self-controlled study with 11 patients taking oral sirolimus. Retrospective data were collected prior to treatment, and prospective data were gathered during the study. Efficacy was assessed primarily by comparing bleeding episodes before and after sirolimus, with measurements at 3 and 6 months post-administration. The initial dose was 0.8 mg/m² once daily, adjusted to maintain trough blood concentrations between 5-10 ng/mL. Secondary outcomes included hemoglobin (Hb) levels, blood transfusion volume, and vascular lesions. Safety was monitored by tracking adverse reactions.
resultsThe average number of bleeding episodes decreased significantly from 2.09 ± 1.04 to 1.00 ± 0.75 in the 3 months preceding treatment, and from 3.80 ± 1.93 to 2.00 ± 1.63 in the 6 months preceding treatment. Sirolimus also increased Hb levels, reduced the need for transfusions, and decreased vascular lesions, improving clinical outcomes. All adverse effects were mild and resolved or improved within 1 week to 1 month without stopping sirolimus or needing lipid-lowering treatment.
conclusionSirolimus reduced bleeding and transfusion needs while improving Hb levels in GIAD patients. Although these findings are encouraging, the limited sample size and lack of a control group warrant caution. Future controlled trials with larger populations are needed to validate sirolimus's potential in GIAD.
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Registered trials
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