Evidence map›Paper›PMID 40656838›Full record

ArticleRSC medicinal chemistry2025

Design, synthesis, and apoptotic antiproliferative efficacy of new quinazoline/1,3,4-oxadiazole-2-thione derived EGFR/HER-2 dual inhibitors with anti-breast cancer activity.

Hesham A M Gomaa, Mohamed E Shaker, Sami I Alzarea, Tariq G Alsahli, Abdullah Salah Alanazi, Fatma A M Mohamed, Mashael Naif Alanazi, Hesham A Abou-Zied, Alshaimaa Abdelmoez, Stefan Brase and 2 more

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hesham A M GomaaDepartment of Pharmacology, College of Pharmacy, Jouf University Sakaka 72388 Saudi Arabia hasoliman@ju.edu.sa.ORCID https://orcid.org/0000-0001-7510-8428
Mohamed E ShakerDepartment of Pharmacology, College of Pharmacy, Jouf University Sakaka 72388 Saudi Arabia hasoliman@ju.edu.sa.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University Sakaka 72388 Saudi Arabia hasoliman@ju.edu.sa.
Tariq G AlsahliDepartment of Pharmacology, College of Pharmacy, Jouf University Sakaka 72388 Saudi Arabia hasoliman@ju.edu.sa.
Abdullah Salah AlanaziDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University Saudi Arabia.
Fatma A M MohamedDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences at Al-Qurayyat, Jouf University Al-Qurayyat 77454 Saudi Arabia.
Mashael Naif AlanaziDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University Rafha 91431 Saudi Arabia.
Hesham A Abou-ZiedMedicinal Chemistry Department, Faculty of Pharmacy, Deraya University Minia Egypt.ORCID https://orcid.org/0000-0001-6993-3325
Alshaimaa AbdelmoezPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt bgyoussif2@gmail.com +20 (002) 01044353895.
Stefan BraseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology 76131 Karlsruhe Germany braese@kit.edu.ORCID https://orcid.org/0000-0003-4845-3191
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt bgyoussif2@gmail.com +20 (002) 01044353895.ORCID https://orcid.org/0000-0002-6834-6548
Mohamed T-E MaghrabyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, New Valley University New Valley 72511 Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of new multi-target inhibitors derived from quinazoline and 1,3,4-oxadiazole-2-thione were designed, synthesized, and tested

Identifiers

PMID40656838
PMCPMC12242836

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.