Trial reportNeuropsychiatric disease and treatment2025
Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the "Microbiota-Gut-Brain Axis" Theory: A Randomized Controlled Study.
Trial report in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychobiotic, nutritional, and behavioral interventions targeting the microbiome-gut-brain axis in depression, anxiety, and stress: a scoping review.Frontiers in nutrition · 2026Pooled it
- Gut microbiota-mediated neuroinflammation following stroke: mechanisms and intervention strategies.Journal of translational medicine · 2026Review
- Does the Microbiota-Gut-Brain Axis Mediate the Antidepressant Effects of Acupuncture? A Structured Review of Preclinical and Clinical Evidence.Neuropsychiatric disease and treatment · 2026Review
- Acupuncture treatment for Sjögren's syndrome: a narrative review on mechanism of treatment and clinical application.Frontiers in immunology · 2026Review
- Acupuncture modulates the microbiota-gut-brain axis to treat irritable bowel syndrome: a mechanistic exploration.Frontiers in neuroscience · 2026Review
- Central Neurobiological Mechanisms of Acupuncture in Post-Stroke Depression: Multi-Target and Network-Based Regulation.Neuropsychiatric disease and treatment · 2026Review
- Traditional Chinese Medicine Ameliorates Depression via the Gut-Brain Axis: A Review Focus on NLRP3/TLR4-Mediated Inflammatory Pathways and Gut Microbiota Modulation.Neuropsychiatric disease and treatment · 2026Review
- Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network.Frontiers in immunology · 2026Review
- Reassessing the Role of Mind-Regulating Acupuncture in Post-Stroke Depression: Promising but Not Yet Definitive [Letter].Neuropsychiatric disease and treatment · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the "microbiota-gut-brain axis" theory. Methods: 92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared. Results: MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones. Conclusion: MRA effectively treats PSD, and its mechanism may involve regulating the "microbiota-gut-brain axis", increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.