ArticlePeerJ2025
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sorafenib is a multi-targeted tyrosine kinase inhibitor (TKI) used for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma (HCC), and radioactive iodine-resistant thyroid carcinoma. Notably, glucose transporters sodium-glucose cotransporter 2 (SGLT2) and glucose transporter 1 are highly expressed in HCC and functionally promote tumorigenicity, which increase the possibility of coadministration of TKIs with SGLT2 inhibitors. Therefore, this study aimed to investigate the pharmacokinetic profiles of coadministration of sorafenib with novel SGLT2 inhibitors, either empagliflozin or henagliflozin and to explore their potential mechanisms. Methods: Male Sprague-Dawley (SD) rats were divided into seven groups ( Results: The study revealed that sorafenib slightly increased the plasma concentration-time curves (AUC Conclusions: These pharmacokinetic interactions provide valuable insights for future studies on optimizing the dosing regimens of sorafenib in combination with empagliflozin or henagliflozin, potentially reducing toxicity risks and improving the safety of coadministration in clinical settings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.