ArticleSmall science2025
Shear Stress and Microbubble-Mediated Modulation of Endothelial Cell Immunobiology.
Article in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Ultrasound triggered microbubbles enhance the diagnosis and therapy of colorectal cancer.Discover nano · 2026Review
- Emerging nano-immunotherapeutic strategies achieve metastatic colorectal cancer precision therapy.Journal of nanobiotechnology · 2026Review
- Mechanical properties of the tumor microenvironment: drivers of immunotherapy resistance in solid tumors.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular immunotherapy remains hindered in the context of solid tumors due to the immunosuppressive microenvironment, in which key endothelial cell adhesion molecules (CAM) are suppressed. Microbubble-mediated focused ultrasound is being explored for targeted immunotherapy and can exert local shear stress upon neighboring endothelial cells. However, fluid and microbubble-induced shear modulation of endothelial immunobiology is not well understood. Herein, the influence of both types of shear stress on human endothelial vein (HUVEC) and brain endothelial (HBEC-5i) CAM expression and secretion of over 90 cytokines using acoustically coupled microscopy is examined. Fluid flow results in time-dependent modulation of CAM expression, where ICAM-1 peaked at 4 h (1.98-fold,
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Registered trials
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