ReviewSmall science2025
Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications.
Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Porous Micropillar Arrays with Oil Infusion: Fabrication, Characterisation, and Wettability Analysis.Micromachines · 2025Article
- A Voronoi-Diagram-Based Load Transfer Rule: An Application to Damage Evolution in Suddenly Loaded Arrays of Pillars.Materials (Basel, Switzerland) · 2025Article
- Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics.Development, growth & differentiation · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells possess the remarkable ability to sense and respond to mechanical cues from their extracellular environment, a phenomenon known as mechanobiology, which is crucial for the proper functioning of biological systems. Micropillars have emerged as a prominent tool for quantifying cellular forces and have demonstrated versatility beyond force measurement, including the modulation of the extracellular environment and the facilitation of mechano-stimulation. In this comprehensive review, innovative strategies in micropillars' design, fabrication, characterization, and biosensing applications are explored. The review begins with a foundational overview of micropillar-based cell mechanobiology studies to provide a complete understanding, and then it delves into novel methodologies within each domain. The latter part of the review unveils innovative micropillars' applications beyond mechanobiology, such as their use in enhancing biosensing surfaces and as upstream fluid manipulators for biosensors. Finally, in this review, future research directions are discussed and the current limitations of these techniques are outlined. Despite the extensive exploration of micropillar applications, a significant gap remains between research advancements and the practical implementation of micropillars in point-of-care diagnostics. Bridging this gap is crucial for translating laboratory innovations into real-world medical and diagnostic tools.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.